To properly handle large file attachments it is often necessary to modify settings in your HelpSpot, PHP.ini file and database configuration.
Admin->Settings->Email Integration->Max Attachment Size - This defaults to 10mb. If you need to handle larger sizes, you'll first need to increase this setting.
memory_limit - PHP may require more memory to import large files then it has available. Increasing this value will give PHP more memory to use. 60mb has proven to be a good value for this variable if you want to handle attachments up to about 10mb.
max_execution_time - The time PHP has to execute a script. If you're downloading large files from across the internet, you may need more time.
upload_max_filesize - The maximum size a file upload can be. This affects files staff try to upload to attach to emails.
post_max_size - The maximum size an HTTP POST request can be, this can limit the maximum size a file can be when uploading files to attach to emails.
upload_tmp_dir - The directory uploaded files are temporarily stored in during transmission. If no attachments of any size are able to be uploaded then this value may be unset or set to a directory which is not writable by the web server.
MySQL: max_allowed_packet - On MySQL, increase the max packet size to greater than the biggest files you expect to handle. This is done in the MySQL configuration file. See your MySQL documentation for specific instructions for your version.